On the cover: In this issue of Molecular Cell, Chen et al. probe the 3D structure of the human SOX9 locus during differentiation. Pronounced changes in locus topology can be observed between cell types. These ensemble-average differences arise through changes in the frequency of commonly sampled structures. This is akin to a dance, where an overlapping set of movements or steps arranged distinctly can result in different dances. The image depicts these dynamic DNA structures as dancers, with two groups of dancers representing two different cell types. Artwork: Mesa Schumacher.
